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Question: I'm severe factor 7 deficient suffering from arthritis pain in left knee and both ankles. Is there any way to reduce pain rather than any surgical procedure as i can't afford or get factor for free.
Severe FVII deficiency is a condition that warrants (in my opinion) rFVIIa prophylaxis, as the risk of life-threatening bleeding is quite high, and many having intracranial hemorrhages, often early in life. Prophylaxis is the only true way to prevent significant joint bleeds. You can discuss with your local HTC some pain control methods including selective COX-2 inhibitors like Celebrex, as there are some side effects to consider. Additionally you should discuss potential alternative therapies (discuss with your local HTC to ensure no anti-platelet effects) depending on your state's laws. Strategies of isometric exercise techniques that your local PT can discuss such as yoga and core exercises to ensure the muscles around the joints are strong. Also use of Kinesiology tape (you have likely seen NBA players and volleyball players using it during games) may be helpful and can be used by your local PT.